(Note: While purists might argue that Hexadoku refers specifically to the 16-character alphanumeric set, some variations use numbers 0-9 plus letters A-F, or even 1-16. The alphanumeric 1-9, A-G standard is the most common for printable puzzles to maintain single-character readability).
: The increased complexity requires greater focus and memory to track potential candidates across a larger area. Stress Relief
16 x 16 sudoku puzzles work just the same as regular 9 x 9 sudoku puzzles, but they are, well, a lot bigger! 16x16 Sudoku - Puzzle Genius
Unlike 9x9, you will rarely find a "Hidden Single" without notes. Use a systematic notation:
With 16 possible candidates per cell, you cannot solve a Hexadoku in your head or with simple pencil marks. You need to write tiny numbers (pencil notes) in the corners of cells. Doing this with a mouse or finger is slow; doing it with a mechanical pencil on high-quality print paper is therapeutic.