Siberian-mouse-hd-154-msh2-003 | Recommended |

The HD-154 (MSH2-003) strain of Siberian mouse is a remarkable example of genetic engineering. This strain has been specifically designed to carry a mutation in the MSH2 gene, which plays a crucial role in DNA mismatch repair. The mutation, known as MSH2-003, leads to a deficiency in DNA repair mechanisms, making these mice highly susceptible to genetic mutations and cancer.

The MSH2 gene mutation in the Siberian mouse HD 154 has significant implications for our understanding of genomic stability and the development of cancer. The MMR system, and the MSH2 gene in particular, play a critical role in maintaining the integrity of the genome. Deficiencies in the MMR system have been implicated in a range of human diseases, including Lynch syndrome, a hereditary form of colorectal cancer. siberian-mouse-hd-154-msh2-003