If using homebrew tools like Open PS2 Loader (OPL), you can use Virtual Memory Cards (VMC) . However, if you prefer physical saves, you must disable the VMC feature in the game settings. Unlockables Tied to Save Data
For a visual guide on installing or modifying save data for both hardware and emulators like AetherSX2: Save Data Game Resident Evil 4 MFD Ghost KX YouTube• May 30, 2024 Resident Evil 4 - Corrupt save? - GameFAQs Save Data Resident Evil 4 Ps2