The film received mixed to negative reviews from critics. On Rotten Tomatoes , it holds a low rating, with critics citing a weak plot and uneven performances. While Manoj Bajpayee's performance was noted as a highlight, the overall execution was widely panned for being "unintentionally funny" and lacking suspense.

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By choosing to watch "Mrs. Serial Killer" on these platforms, viewers can ensure that they are supporting the creators and contributing to the production of high-quality content.