Yes, but only with Methods 2 or 4. The 24H2 update hardened kernel security, making Method 1 less reliable.
Often the most stable for Windows 11.
There are two primary driver chipsets used in Opcom V2 cables. You must identify which one you have by looking at the circuit board (if you can open the casing) or by plugging it in and checking the "Hardware ID" in Device Manager. opcom usb v2 driver windows 11