Gata-2

: As a zinc-finger protein, it binds to DNA sequences (WGATAR motif) to regulate hundreds of genes The "GATA Switch"

Unlike aplastic anemia, growth factors may accelerate MDS progression in GATA-2. Generally avoided unless absolutely necessary. gata-2

Since GATA-2 is tightly regulated, simply overexpressing it causes leukemia. Investigators at the NIH are currently testing a lentiviral vector that places a full-length GATA-2 cDNA under a weak, endogenous promoter to avoid overexpression. Phase I trials are recruiting. : As a zinc-finger protein, it binds to