A memory leak can crash the worker process, triggering a 500 error until the pool recycles.

The SolarWinds Orion Error 500 is an internal server error that occurs when the SolarWinds Orion server encounters an unexpected condition that prevents it from fulfilling a request. This error is usually displayed as a generic "500 Internal Server Error" message, without providing much information about the root cause.

C:\Windows\Microsoft.NET\Framework64\v4.0.30319\Temporary ASP.NET Files folder resolves stubborn web UI crashes. Are you seeing this error after a specific server migration

Ensure the local Network Service account has Full Control over C:\inetpub\SolarWinds\ .