Unlike "class-compliant" devices (which work instantly when you plug them in via USB), the Line 6 UX1 requires dedicated software drivers to communicate with your computer. These drivers tell Windows 10 exactly how to handle the audio data streaming through the USB cable.
Here’s a concise, helpful summary based on community and official sources. line 6 ux1 driver windows 10
Now, with driver enforcement disabled, follow this exact sequence: with driver enforcement disabled
Windows 10 installed a generic USB driver over your Line 6 driver during a system update. Fix: line 6 ux1 driver windows 10