For Paint Tool SAI 2, a portable setup means you can keep the entire program on a USB flash drive or an external hard drive. You can plug that drive into any Windows computer, double-click the executable, and your art studio—complete with your custom brushes and hotkeys—launches instantly.
Many drawing tablets (Huion, XP-Pen, older Wacoms) allow you to install drivers on the fly. Keep a copy of your tablet driver installer on the same USB drive. paint tool sai 2 portable
However, The risk of credential theft is simply too high. Your art is valuable; your bank account is more so. For Paint Tool SAI 2, a portable setup