Bioprocess Development Extra Quality: A Mab A Case Study In

Once the cell line is selected, the focus shifts to Upstream Processing (USP). This involves scaling the culture from a few milliliters in a shake flask to thousands of liters in a stainless steel or single-use bioreactor.

If you'd like to dive deeper into a specific part of this case study, let me know: (Cell line engineering or feeding strategies) Downstream (Chromatin removal or resin lifetime studies) Analytical (Mass spectrometry or potency assays) A Mab A Case Study In Bioprocess Development

Upstream processing (USP) accounts for roughly 60% of the cost of goods for a mAb. For Mab-A, the goal was to achieve a titer of >5 g/L while maintaining quality. Once the cell line is selected, the focus