This force field, derived from Shaw’s own measurements of peptide dihedral angles, specifically corrected the over-compactness of unfolded states. Now, when a researcher uses CHARMM36m, they are indirectly using a "Dee Shaw measurement" as their foundation.
Shaw concluded that general-purpose hardware was insufficient. So, he built a specialized supercomputer: (named after the 17th-century inventor Anton van Leeuwenhoek, the first to observe microbes).
| Feature | Experimental Measurement (e.g., FRET) | Dee Shaw Measurement (Anton MD) | | :--- | :--- | :--- | | | ~2-5 Angstroms (indirect) | <0.1 Angstroms (direct atomic coordinates) | | Temporal Resolution | Microseconds to seconds (if lucky) | Femtoseconds to milliseconds | | Observable | Distance between two tags | Trajectory of every single atom | | Noise | High (shot noise, photobleaching) | Deterministic (limited only by force field accuracy) |
, where she appeared in roughly 85 episodes between 1989 and 1995. Her character's progression from Corporal to Sergeant mirrored the show’s themes of professional growth and community policing. Beyond the precinct, her notable credits include: Savannah (1996): Appeared as Worker #1. My Name Is Earl (2005): Played an uncredited role as Mrs. Turner. The Last Adam (2006): Played the character Trish in this feature film. Where is She Now?