From the opening moments, declares that this is a show unafraid of high-concept medical horror. The sight of doctors in hazmat suits while a patient bleeds from his eyes set a new bar for network TV tension. But the true genius is how Rhymes uses the medical crisis to force emotional intimacy. Locked in a quarantine room, Meredith and Derek must confront the fact that "his wife is coming" isn't just an inconvenience—it's a bomb waiting to go off.
We began to see the cracks in his "evil spawn" armor, particularly through his failures in his board exams and his budding (and failing) relationship with Izzie. Greys Anatomy - Season 2 Complete