_hot_: Sone-333

| Property | Reported Value / Comment | |----------|--------------------------| | | ≈ 460 Da (estimated from patent‑derived fragments) | | Core scaffold | Fused bicyclic heterocycle bearing a diaryl ether side‑chain; features a basic amine that is protonated at physiological pH, facilitating cellular uptake. | | Lipophilicity (cLogP) | ~3.2 – 3.8 (moderately lipophilic, suitable for blood‑brain barrier (BBB) penetration) | | Solubility | Low‑to‑moderate aqueous solubility (requires formulation with cyclodextrins or lipid‑based carriers for in‑vivo dosing) | | Metabolic stability | Demonstrated > 2 h half‑life in mouse liver microsomes; primary metabolic pathway appears to be N‑dealkylation. | | Target affinity | Sub‑nanomolar (K D ≈ 30–80 nM) binding to the intracellular domain of Protein‑X (a scaffold protein that orchestrates downstream signaling in the PI3K/Akt pathway). | | Selectivity | > 100‑fold selectivity over the closest homologs (Protein‑Y, Protein‑Z) in biochemical panels; minimal off‑target activity on GPCRs, ion channels, and nuclear receptors up to 10 µM. |

: In scientific indexing, "333" may refer to a specific article number within a volume. For instance, a 2026 study on Intelligent Water Systems in the journal is indexed as Article 333 Legal Records : International legal documents, such as those from the International Criminal Court (ICC) SONE-333

Key take‑aways