No advanced discussion of parasitology is complete without addressing the macroecological forces shaping parasite distribution. The 21st century is witnessing an unprecedented rearrangement of parasite geographies.
Consider Schistosoma mansoni , the blood fluke causing intestinal schistosomiasis. Adult schistosomes can live within human mesenteric veins for decades. How do they avoid immune attack? They wrap themselves in a double lipid bilayer that becomes coated with host antigens—a process called . The parasite absorbs host blood group antigens and major histocompatibility complex (MHC) molecules onto its surface. To the host’s T-cells, the worm appears as “self.”
As climate change alters global ecosystems, the distribution and transmission of parasitic diseases are shifting rapidly. Trends in Parasitology: Cell Press
Conflict creates ideal transmission conditions. The collapse of water and sanitation infrastructure in Yemen (2015–present) led to a surge in Schistosoma haematobium (causing urogenital schistosomiasis) among internally displaced children. Similarly, Russian invasion of Ukraine disrupted control programs for Dirofilaria immitis (heartworm) in companion animals, raising spillover risks to humans. Parasitology 2 now includes a module on —the study of disease emergence following the destruction of public health systems.
: While some find the complex web of character goals riveting, others criticize the book for "second book syndrome," feeling the plot stalls or becomes repetitive in its roughly 500-page length. Key Highlights and Critiques