Meyd-873

| Model | Species | Dosing Regimen | Primary Endpoint | Effect vs. Vehicle | |-------|---------|----------------|------------------|--------------------| | | Mouse (DBA/1) | 10 mg kg⁻¹ p.o., BID, 14 d | Clinical arthritis score | ↓ 63 % (p < 0.001) | | Bleomycin‑induced Pulmonary Fibrosis | Rat (Sprague‑Dawley) | 30 mg kg⁻¹ p.o., QD, 21 d | Lung hydroxyproline content | ↓ 55 % (p < 0.01) | | MOG‑EAE (experimental autoimmune encephalomyelitis) | Mouse (C57BL/6) | 15 mg kg⁻¹ p.o., BID, from day 0 | Max clinical score | ↓ 48 % (p < 0.05) | | Human LPA₅‑overexpressing Xenograft (HT‑1080) | SCID mouse | 30 mg kg⁻¹ p.o., QD, 21 d | Tumor volume | No significant inhibition (consistent with target relevance) |

At its core, MEYD-873 is a unique identifier that could be associated with a product, a document, a project, or even a specific process. Without more context, it's challenging to pinpoint exactly what MEYD-873 refers to. However, we can speculate that it's a code used to streamline information management, enhance organization, or facilitate quick lookup and retrieval. MEYD-873

| Disease | Evidence | |---------|----------| | | Elevated LPA₅ expression in synovial macrophages of RA patients (J. Immunol., 2022). | | Fibrosis | LPA₅ knockout mice display reduced lung and liver collagen deposition after bleomycin or CCl₄ challenge (Nat. Commun., 2021). | | Cancer metastasis | LPA₅ promotes cell migration in melanoma and breast cancer models (Oncogene, 2023). | | Model | Species | Dosing Regimen |

| Property | Value | |----------|-------| | | 4‑[(3‑trifluoromethyl‑5‑pyridinyl)amino]‑N‑[2‑(1‑pyrrolidinyl)ethyl]‑benzenesulfonamide | | Synonyms | MEYD‑873, 5‑(3‑CF₃‑5‑pyridinyl)‑aminobenzenesulfonamide derivative | | Molecular formula | C₁₈H₁₉F₃N₃O₂S | | Molecular weight | 389.4 g·mol⁻¹ | | SMILES | FC(F)(F)c1ccnc(c1)Nc2ccc(S(=O)(=O)NCCN3CCCC3)cc2 | | LogP (XlogP3‑AA) | 2.9 | | pKa (basic amine) | 7.6 (estimated) | | Solubility | ~ 45 µM in pH 7.4 phosphate buffer; >10 mM in DMSO | | Stability | Chemically stable (≥ 90 % intact after 48 h at 37 °C, pH 7.4) | However, we can speculate that it's a code

These data were presented at the 2025 American College of Rheumatology (ACR) Annual Meeting (abstract #1256) and at the 2025 European Respiratory Society (ERS) Congress (poster #P‑321).