The number one killer of playthroughs is a bad load order. Follow this template religiously:

Welcome to the ultimate edition. In this comprehensive article, we will walk you through everything you need to know to transform a dated 2015 RPG into a modern, visually stunning, and mechanically deep survival simulator.

If you don't want to spend 3 hours reading descriptions, install this 10-mod "Vanilla+" list in this exact order via MO2:

These mods do nothing flashy, but you will never play without them again.