Squamous cell carcinoma of the anal margin may present as a firm, ulcerated area with obliteration of adjacent rugae. Any localized loss of rugae with induration warrants biopsy.

If you intended a different meaning for "rugiuose prie bedugnes" , please provide the correct spelling or context (e.g., geological, literary, or statistical). I will gladly rewrite the article accordingly.

A systematic analysis of anal rugae — inspection, palpation, and sometimes imaging — can uncover numerous anorectal disorders.